This column is based on an ultra-pure silica gel (more than
99.99%) with carbon content of only 8.5%. Therefore the retention
of polar compounds is relatively longer than that on the C18-MS-II
or C18-AR-II. This column is
also suitable for the analysis of a wide range of chemical
compounds including polypeptides.
Material characteristics
COSMOSIL
5C18-P-MS
Silica
gel
high purity porous spherical
silica
Average
particle size
5µm
Average
pore size
approx. 120Å
Specific
surface area
approx. 300m²/g
Stationary
phase
monomeric type octadecyl group
End
capping treatment
near-perfect treatment
Carbon
content
approx. 8.5%
Comparison data using
different COSMOSIL C18 columns
The COSMOSIL 5C18-P-MS gives
quicker separation of most samples compared with other COSMOSIL 5C18
type columns. However, there is a characteristic by which the
polar compounds are retained relatively longer on the COSMOSIL 5C18-P-MS.
Separation of di-substituted
benzene isomers
Because their characteristics (eg. polarity) and structure is
very similar, isomers of di-substituted benzene are one of the
most difficult samples to separate. It is possible to separate
them at a high probability by using either any or a combination of
three types of COSMOSIL C18 (MS-II, AR-II, P-MS).
