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Cosmosil C18-PREP Packing Materials

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Reversed phase liquid chromatography has been widely used due to its separation characteristics, high theoretical plate number, reliable reproducibility and ease of use.
However high performance large-scale columns for preparation and purification are very expensive and many chromatographers need less expensive preparation and purification techniques.
The particle sizes that are most generally used for analytical separations have been 5 and 10m. However many large scale separations don't require such a small particle size and 40 or 140m sized packing material is sufficient for large scale separations.
The COSMOSIL C18-PREP is a conventional C18 packing material based on totally porous spherical silica, which can be effectively used for medium pressure and open column chromatography. There are three different particle sizes, as outlined in the table below.
Material characteristics

40C18-PREP 75C18-PREP 140C18-PREP

Silica gel

totally porous spherical silica

Average particle size

40 m

75 m

140 m

Average pore size

approx. 120

Specific surface area

approx. 300m2/g

Stationary phase

octadecyl group

End capping treatment

near-perfect treatment

Carbon content

approx. 19%

Application

flash column chromatography

flash or open

column chromatography

Particle size, flow rate and theoretical plate number
Because reversed phase chromatography employs effluents of high viscosity such as methanol and water, the flow rate is lower than that of normal phase chromatography which uses effluents of low viscosity such as hexane and ethyl acetate.
Ordering information
PRODUCT NAME CODE No. PACKING SIZE
COSMOSIL 40C18-PREP

37932-86

100g

37932-15

500g

37932-31

1kg

COSMOSIL 75C18-PREP 37933-76

100g

37933-05

500g

37933-21

1kg

COSMOSIL 140C18-PREP

37934-66

100g

37934-95

500g

37934-11

1kg

 
 

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